CASP4 and central nervous system cancer: Figures 7F,G show the seven-step cycle underlying the involvement of CASP4 in anticancer immunity in gliomas: Step 1, cancer cell antigen release; Step 2, cancer antigen presentation; Step 3, induction and activation; Step 4, migration of immune cells toward the tumor; Step 5, immune cell infiltration of the tumor; Step 6, recognition of the cancer cell by T cells; and Step 7, killing of the cancer cell.