TNF and colorectal cancer: KEGG pathway enrichment analysis showed that the six pyroptosis-related hub genes were enriched mainly in the Nucleotide-binding Oligomerization Domain (NOD)-like receptor, cellular DNA sensing, p53, IL-17, C-type lectin receptor, and Tumor Necrosis Factor (TNF) signaling pathways, as well as platinum resistance, colorectal cancer, and small cell lung cancer (Fig. 3B).