The NOD-like receptor signaling pathway is central to the pathogenesis of many cancers and neurodegenerative diseases, and NOD-like receptor signaling contributes to the angiogenesis of gliomas, with NLRP3 being an important component, which promotes the growth and invasion of gliomas through IL-1β/NF-κB p65 signaling39,40. The gene discussed is NFKB1; the disease is central nervous system cancer.