Nonetheless, there was a protective ‘legacy effect’ from the prior weight loss with liraglutide, such that renal functional and structural changes, as measured by albuminuria, renal fibrosis-related changes (Col IV and FN) and oxidative DNA damage (8-OHdG) were lower at late gestation, despite the accelerated weight gain in pregnancy. Here, FN1 is linked to renal fibrosis.