Through further analysis of single-cell RNA-seq data and using the latest approaches in spatial transcriptomics, we highlight the spatial proximity of SPP1+APOE+ TAM and CTHRC1+GREM1+ myCAF that concordantly contribute to the establishment of a pro-tumor TME involving immuno-regulatory, pro-fibrotic, EMT, and other mechanisms. The gene discussed is CTHRC1; the disease is neoplasm.