In this study, we found that CTHRC1+GREM1+ myCAF were enriched in tumor patients and expressed significantly higher levels of matrix-associated genes such as proteoglycans (ACTB, DCN), collagens (COL1A2, COL3A1), and matrix metalloproteinases (MMP2, MMP11, MMP14), indicating fibrotic properties and contributing to worse overall survival. Here, ACTB is linked to neoplasm.