In this study, we unveil a distinct population of TAM characterized by SPP1 and APOE along with another population of myCAF expressing CTHRC1 and GREM1. Using single cell transcriptomics, we establish a high degree of correlation, highlighting their contributions in immune-suppressive capacities, driving ECM deposition, facilitating matrix remodeling, and EMT, consequently fueling tumor progression. This evidence concerns the gene SPP1 and neoplasm.