NUP88 and colorectal carcinoma: In a similar fashion, the direct binding of the lncRNA MILNR1 to the MYC protein alters its transactivation of NUP88. Interestingly, MILNR1 is normally downregulated in CRC cells with its gene occurring close to NUP88. Among neighboring genes, MILNR1 appears to selectively inhibit NUP88 transcription by preventing MYC recruitment to the NUP88 promoter [73].