SENEBLOC prevents CRC cells from triggering cell senescence by preventing the induction of the senescence initiator, CDKN1A. Firstly, SENEBLOC functions as a ceRNA with miR-3175, stabilizing HDAC5 expression which results in epigenetic silencing at the CDKN1A gene promoter. The gene discussed is CDKN1A; the disease is colorectal carcinoma.