LARP1 and inflammatory breast carcinoma: Furthermore, based on recent studies reporting cell cycle-independent function of CDK1 in coupling proliferation with activation of eIF4E protein synthesis38 via its ability to phosphorylate translational regulators/repressors including eIF4BP139, LARP1 involved in regulating 5’ Terminal OligoPyrimidine (5′ TOP) motif-containing mRNAs40,41, RPS342, we envision employing this preclinical IBC model to evaluate the efficacy of CDK1 inhibitors alone and in combination with TKIs and other chemotherapeutics.