Although self-reported race did not emerge as a significant variable, individuals who were Hispanic/Latino were more likely to have PRKN variants (biallelic) consistent with observations in the CORE-PD study in which those who were Hispanic were more likely to have PRKN variants than non-Hispanic individuals.12 Since we did not report back VUS by design, as additional variants are adjudicated in ClinGen/ClinVar using patient materials from this and other large studies, we anticipate that some VUS will be elevated to the status of P/LP and then the positivity rate in our cohort will increase. This evidence concerns the gene PRKN and Parkinson disease.