Specifically, variants in GBA1 and PRKN (biallelic) were associated with earlier AAO, and those with LRRK2 variants were more likely to be self-reported as female, confirming prior observations.6,12 Female predominance among LRRK2 carriers with Parkinson’s disease is not yet fully explained, and our study does not shed further light on this question. This evidence concerns the gene PRKN and Parkinson disease.