Our observations regarding the proinflammatory cytokines differ from those in a study conducted by Mohammad et al, which reports a substantial decrease in the proinflammatory cytokines IL-1β and TNF-α after 6 weeks when comparing SRP with and without 0.8% HA gel.36Regarding anti-inflammatory cytokines, we have not come across a clinical study that focuses on the evaluation of IL-10 specifically in the context of HA treatment for periodontitis. The gene discussed is TNF; the disease is periodontitis.