Our results question whether using an Ag prevalence of <1% in 6-7-year-old children is an appropriate measure to determine whether a country has achieved elimination of LF, given that (i) significantly lower prevalence of both Ag and Ab among this demographic has been reported in several studies to date, and (ii) Ag prevalence is significantly lower than Ab seroprevalence rates, implying the lower sensitivity of Ag to detect LF exposure and infection. The gene discussed is RENBP; the disease is infection.