NOX4 and chronic kidney disease: A previousstudy revealed that diosgenin could suppress high glucose-inducedROS production by reducing NOX4 expression in renal tubular epithelialcells.23 Our current findings further suggestedthat diosgenin administration could not only decrease hypoxia-inducedROS production through its NOX4 inhibition in renal tubular epithelialcells in vitro but also reduce the renal damages during AKI and preventconsequent progression to CKD in vivo.