To identify the families of models that predict HSC behaviors and collagen accumulation that fits with the experimental data from Kiesseleva et al. [24], we conducted simulation studies using the protocol described by the authors for a mouse model of liver fibrosis and reversion, i.e. twice-weekly CCl4 (TGFβ1 in the model) injections for 8 weeks and an overall reversion period of six months. Here, TGFB1 is linked to Hepatic fibrosis.