Other factors could influence the risk of IAC after TKA or THA, as suggested in the article by Basile et al. [25] Among the malnutrition, which we also included in our study as NRI or albumin/prealbumin, intraoperative factors, such as patient-specific factors (e.g. obesity, systemic infections) and surgical conditions (e.g. prolonged surgery, significant blood loss, alongside adherence to aseptic techniques and postoperative care) should be taken into account as risk factors for IAC. This evidence concerns the gene TTR and obesity due to melanocortin 4 receptor deficiency.