CASP1 and rheumatoid arthritis: Patients with AOSD demonstrated significantly higher caspase-1 levels [median: 419.33 ng/ml, IQR (79.19–555.84)] compared to those with RA (6.98 ng/ml, p < 0.001) and HCs (5.85 ng/ml, p < 0.001) (Fig 1).