Notably, all JAG, DLL, and NOTCH families genes, except DLL3 and NOTCH3, showed significant correlations with extracellular matrix (ECM) organization, cell migration, and adhesion, strongly implying that the JAG, DLL, and NOTCH families could play a crucial role in regulating cell motility and cancer invasion (Fig 2B and S5, S6 Figs in S1 File). The gene discussed is NOTCH3; the disease is cancer.