The results revealed that SPOP mRNA expression profiles correlated significantly with AJCC/UICC TNM (Tumor Node Metastasis) stage in patients with BRCA, COAD, ESCA, LUAD, Head and Neck squamous cell carcinoma (HNSC) and STAD (Fig 2A–2F). This evidence concerns the gene SPOP and head and neck squamous cell carcinoma.