SPOP and neoplasm: Tumor mutational burden (TMB) and microsatellite instability (MSI) have been reported as an excellent biomarker to evaluate therapeutic efficiency [20, 21], and prognosis of tumor patients [22], thus, the correlation between TMB, MSI, and SPOP was estimated, our consequences presented that SPOP expression significant positive correlated with MSI in Acute Myeloid Leukemia-like (LAML) and TGCT, significant negative correlations within BRCA, DLBC, HNSC, KICH, KIPAN, LGG, OV, PRAD, STAD, STES, and THCA (Fig 4A).