SPOP and cancer: Tumors are characterized by heterogeneity, with a variety of substances presenting diverse expressions among them, therefore, we first verified the overall expression levels of SPOP in different forms of malignancies, after analyzed the transcriptional profiles of SPOP in 23 different types of cancer by using a free online database called TIMER2.0 (Fig 1A), SPOP was found to exhibit divergent expression levels in numerous cancers.