Then we further explored the expression of the SPOP mRNA expression profiles, a negative correlation with TNM stage and grade in patients with ACC, BRCA, COAD, KICH, KIRC, KIRP, LIHC, LUAD, and THCA the results showed that a lower expression of SPOP always occurred in the advanced stage cancer. The gene discussed is SPOP; the disease is adrenal cortex carcinoma.