Additionally, a same result can be found in non-small cell lung cancer (NSCLC), a lower expression level of SPOP has been detected in NSCLC tissues compared with para-cancer tissues at both the transcriptional and translational levels, a decrease expression of SPOP was also considered a predictor of poor overall survival in patients with NSCLC, suggesting that SPOP could be a potential tumor suppressor in NSCLC [34]. The gene discussed is SPOP; the disease is cancer.