It is known to have antiapoptotic, mitotic, and proangiogenic roles through direct actions via its receptor (Ob-R) and its crosstalk with other oncogenic signaling pathways.12,13,14,15,16 Thus, leptin could be an important part of the nexus of social experiences, obesity, and race-associated BC disparities. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.