It has been reported that ETS1 is upregulated by HIF‐1α and interacts with HIF‐2α to activate the HIF‐1 signaling pathway and promote angiogenesis.[34, 35] Consistently, transcriptome analysis after ETS1 was knocked down in 786‐O cells demonstrated that the renal cell carcinoma signaling pathway, HIF‐1 signaling pathway, and VEGF signaling pathway were inactivated (Figures 3C,D, S3D). The gene discussed is HIF1A; the disease is hereditary clear cell renal cell carcinoma.