It is well known that sunitinib inhibits the phosphorylation of STAT3 in cells.[42, 43] Similarly, we revealed that sunitinib, axitinib, and lenvatinib treatment suppressed the phosphorylation of STAT3 and increased the expression of HDAC8 in ccRCC cells (Figure 7I–K). Here, HDAC8 is linked to nonpapillary renal cell carcinoma.