KEGG and GSEA enrichment analysis of the RNA‐seq data after overexpression of the ETS1‐K245R mutant, which mimics deacetylation at the K245 site, indicated that, compared with WT ETS1, ETS1‐K245R further activated the MAPK, PI3K‐AKT, EGFR TKI resistance, VEGF, and HIF‐1 signaling pathways in ccRCC cells (Figure 5D–F). Here, AKT1 is linked to nonpapillary renal cell carcinoma.