Consistent with the above findings, transcriptome analysis after overexpression of wild‐type ETS1 (ETS1 WT) showed that ETS1 was closely associated with the activation of the MAPK, PI3K‐AKT, EGFR TKI resistance, VEGF, and HIF‐1 signaling pathways in ccRCC cells (Figure 5A–C). Here, VEGFA is linked to nonpapillary renal cell carcinoma.