EPAS1 and renal cell carcinoma: It has been reported that ETS1 is upregulated by HIF‐1α and interacts with HIF‐2α to activate the HIF‐1 signaling pathway and promote angiogenesis.[34, 35] Consistently, transcriptome analysis after ETS1 was knocked down in 786‐O cells demonstrated that the renal cell carcinoma signaling pathway, HIF‐1 signaling pathway, and VEGF signaling pathway were inactivated (Figures 3C,D, S3D).