In many cancers, including breast, colorectal, hepatocellular, and lung cancer cells, higher ETS1 protein or RNA expression is associated with higher grade, poorer differentiation, and/or increased aggressiveness.[56] Previous studies have shown that ETS1 expression is associated with increased microvascular density in tumors.[37] There is growing evidence that ETS1 is involved in drug resistance in cancer cells. The gene discussed is ETS1; the disease is cancer.