HDAC8 and nonpapillary renal cell carcinoma: In contrast, overexpression of wild‐type (WT) HDAC8 or the HDAC8 S39A mutant decreased the acetylation level of ETS1, whereas overexpression of the HDAC8 deacetylate‐defective mutant (HDAC8 S39D).[36] failed to reduce the acetylation level of ETS1 in ccRCC cells (Figure 4C).