Consistent with the above findings, transcriptome analysis after overexpression of wild‐type ETS1 (ETS1 WT) showed that ETS1 was closely associated with the activation of the MAPK, PI3K‐AKT, EGFR TKI resistance, VEGF, and HIF‐1 signaling pathways in ccRCC cells (Figure 5A–C). The gene discussed is AKT1; the disease is nonpapillary renal cell carcinoma.