It has been reported that ETS1 is upregulated by HIF‐1α and interacts with HIF‐2α to activate the HIF‐1 signaling pathway and promote angiogenesis.[34, 35] Consistently, transcriptome analysis after ETS1 was knocked down in 786‐O cells demonstrated that the renal cell carcinoma signaling pathway, HIF‐1 signaling pathway, and VEGF signaling pathway were inactivated (Figures 3C,D, S3D). Here, EPAS1 is linked to hereditary clear cell renal cell carcinoma.