It was reported that M2-polarized (CD206+) TAMs might play a momentous role in the progression of OSCC and ovarian cancer by secreting EGF [54, 55], and PD-L1 expression was increased in M2-polarized (CD68+) TAMs [56, 57], indicating that high infiltration of M2-polarized (CD206+) TAMs in BMC tissues may become a predictive marker for the response to EGFR-targeted treatment, while the high infiltration of M2-polarized (CD68+) TAMs may be an indicator of immunotherapy response. The gene discussed is EGF; the disease is ovarian cancer.