We also found that the uncharacterized fly gene CG3520 (named here as painful reminder (parem) after the SNFU song) is required in peripheral nociceptors for heat nociception and is otherwise unstudied in flies; however, the mammalian ortholog FOCAD is highly expressed in the nervous system, localizes to focal adhesions and stress fibers, and may function as a tumor suppressor in glioma (Brockschmidt et al. 2012). The gene discussed is FOCAD; the disease is central nervous system cancer.