PIK3CA and colorectal carcinoma: Chen et al. considered CRC a disease with complex pathogenesis and easy metastasis and pointed out that its development involves abnormalities in various signaling pathways, such as PI3K/AKT, nuclear factor-κB, mitogen-activated protein kinase, Wnt/β-catenin, epidermal growth factor receptor, tumor protein 53, transforming growth factor-β, and immunoregulatory pathways [33].