Cassio et al. analyzed mutations in the main components of the PI3K/AKT pathway (PI3KCA, phosphatase and tensin homolog (PTEN), PIK3R1, and PIK3R2) and Wnt/β-catenin pathway (APC, CTNNB1, AXIN1, and AXIN2) in several open-access CRC clinical cohorts [32]. This evidence concerns the gene APC and colorectal carcinoma.