TNF and polyarticular arthritis: In this study, we found a significant (p < 0.001) increase in TNF-α and IL1β gene expression in the arthritic group in comparison with normal controls, and this is in agreement with Zhang et al. (2020); interestingly, treatment with M1E and M1G led to a significant (p < 0.001) reduction in their expression in the polyarthritis’ mice in comparison to the indomethacin.