YBX1 is overexpressed in aggressive tumors, acting as an oncogene,[44, 45, 46] including breast cancer.[47, 48] Notably, YBX1 displayed functional importance in autophagy through directly targeting m5C‐containing Ulk1 mRNA or inhibiting the p110β/Vps34/beclin1 signaling pathway.[49] Since YBX1 induced autophagy in other cancers, it showed the opposite effect in TNBC. The gene discussed is PIK3C3; the disease is cancer.