Next, the expression and association of Adcy2 in human patients and rodent models of neurodegenerative diseases (Alzheimer's disease and Parkinson's disease), psychiatric disorders (Tourette syndrome, schizophrenia, and bipolar disorder), and other neurological conditions (stress‐associated disorders, stroke, epilepsy, and Lesch‐Nyhan Syndrome) are elaborated. This evidence concerns the gene ADCY2 and early-onset autosomal dominant Alzheimer disease.