The activation of HIF‐1α/VEGF pathway plays an important part in the regulation of angiogenesis and neuronal survival, whereas the absence of neuronal HIF‐1α inhibited angiogenesis, aggravated neuronal death and impaired neurobehavioral function after focal cerebral ischemia in mice.25, 48, 49. The gene discussed is VEGFA; the disease is Cerebral ischemia.