TOP2A and hepatocellular carcinoma: We first compared the expression differences of MAPT, WDR62, PLK1, CDCA8 and TOP2A in normal hepatocyte tissues and HCC tissues by TCGA database, and the results showed that the expression levels of MAPT, WDR62, PLK1, CDCA8 and TOP2A were significantly higher in tumour cells than in normal tissues (Figure S1).