In order to investigate the regulatory pathways of tumorigenesis in the high LLPSI group, we performed GSEA analysis on the data of HCC samples, and the results showed that the high LLPSI group was significantly enriched in APOPTOSIS, G2M checkpoint, cell cycle, lysosome, mapk signalling pathway, pathways in cancer, VEGF signalling pathway and wnt signalling pathway signalling pathways were significantly enriched (Figure 4A). This evidence concerns the gene VEGFA and cancer.