A previous study revealed that CCR4‐positive Tregs in HCC exhibit enhanced suppressive function to CD8+T‐cells.[11] Consistently, our T‐cell suppression assay and RT‐qPCR assay showed that Tregs from SOX12‐overexpressed tumors had reinforced immunosuppressive activity and expressed higher effector cytokines. The gene discussed is CD8A; the disease is hepatocellular carcinoma.