A previous study revealed that CCR4‐positive Tregs in HCC exhibit enhanced suppressive function to CD8+T‐cells.[11] Consistently, our T‐cell suppression assay and RT‐qPCR assay showed that Tregs from SOX12‐overexpressed tumors had reinforced immunosuppressive activity and expressed higher effector cytokines. This evidence concerns the gene CCR4 and hepatocellular carcinoma.