This upregulated expression of SOX12 was subsequently suppressed by a TGF‐β1 neutralizing antibody or the TGF‐β1 receptor I (TGFβR1) inhibitor galunisertib, indicating that Tregs‐secreted TGF‐β1 stimulated SOX12 overexpression in HCC (Figure S12G, Supporting Information). Here, TGFBR1 is linked to hepatocellular carcinoma.