Chemokines and cytokines are important factors leading to the accumulation and activation of Treg in HCC, such as CCL22 and IL‐33.[30, 31] Among them, CCL22 and its receptor CCR4 are crucial for cell migration and homing of Tregs and Th2 cells, thus promoting HCC development and metastasis.[30, 32] Inhibiting the CCL22/CCR4 axis impairs intratumoral Treg infiltration without affecting conventional CD4+T‐cells, underscoring the specific chemotactic role of CCL22/CCR4 in intratumoral Tregs.[18] Here, we identified CCL22 as a key target of SOX12 through RNA‐sequencing and ChIP‐sequencing. Here, CD4 is linked to hepatocellular carcinoma.