SOX12 and colorectal cancer: The SOX family is essential in cell fate decisions involving numerous developmental processes.[12] Once dysregulated, SOX proteins act as master regulators mediating the malignant progression of tumors.[13] We previously demonstrated that SOX12, a member of subgroup C of the SOX family, is significantly upregulated in gastric cancer, colorectal cancer, and HCC and acts as an oncogene to facilitate their progression and metastasis.[14, 15, 16] However, whether SOX12 participates in regulating the TIME of HCC remains unknown.