In this model, the results we obtained were consistent with those indicated in the hepatocyte‐specific SOX12 knockout model established using the AAV8‐TBG‐Cre system, demonstrating a remission of DEN/CCl4‐induced tumor burden, mouse mortality, lung metastasis, and impaired liver function (Figure 2G–J; Figure S4J, Supporting Information). The gene discussed is SOX12; the disease is neoplasm.