In a previous study, it was noted that inhibition of CCR4 led to a reduction in the proportion of PD‐1+CD8+T‐cell in HCC, which represents a subset of exhausted T‐cells.[11] In addition, PD‐L1 is a key molecule that promotes T‐cell exhaustion.[19] We hypothesized whether SOX12 plays a role in regulating T‐cell exhaustion. The gene discussed is CD8A; the disease is hepatocellular carcinoma.