To investigate the potential role of SOX12 in the DEN/CCl4‐induced HCC progression and metastasis, we constructed a hepatocyte‐specific SOX12 knockout model utilizing the adeno‐associated virus‐serotype 8 (AAV8)‐thyroxine‐binding globulin promoter (TBG)‐Cre recombinase system (Figure S4A,B, Supporting Information). The gene discussed is SOX12; the disease is hepatocellular carcinoma.