MAPT and neurodegenerative disease: Oxidative stress can aggravate the phosphorylation of tau proteins in neuronal cells, which is an important pathological factor inducing neurodegenerative diseases including AD30 Therefore, we next examined the expression and phosphorylation of tau proteins in N2a cells after exposure to H2O2 and, furthermore, compared the effectiveness of treatments with melatonin, coenzyme Q10, lecithin, or in combination.