Noteworthy, in an independent diagnostic screening, in family members of the paternal side (III‐3) and the sister (IV‐2) of the index patient, a KRT5 pathogenic variant c.560G>C p.(Arg187Pro) was found, establishing the diagnosis of localized epidermolysis bullosa simplex (EBSloc).17 This evidence concerns the gene KRT5 and epidermolysis bullosa simplex.