There are also more tumor-associated macrophages (TAM), specifically M2 macrophages in tumors in Black patients (12) which may contribute to CD8+ T cell exhaustion (13, 14).CD8+ T cell exhaustion is a dynamic process where effector CD8+ T cells progressively lose their cytotoxic function and ability to produce effector cytokines. The gene discussed is CD8A; the disease is neoplasm.