Not surprisingly, immunization with two doses of MVA-VP2 or MVA-VP2-NS1-2A-NS2-Nt completely protected mice from BTV-4M infection (Figure 3H), with significantly lower RNA levels at 3 d.p.i. (MVA/MVA-VP2 Ct value mean = 33.706; MVA/MVA-VP2-NS1-2A-NS2-Nt Ct value mean = 37.042) compared to the non-immunized animals and with nearly undetectable RNAemia at 5 and 7 d.p.i., before viral clearance (Figure 3I). Here, LZTR1 is linked to infection.