Additionally, we aspire to integrate lymphocyte proliferation assays into routine practice and develop new functional tests, such as the assessing of histone H2AX phosphorylation (γH2AX) in CD3 T cells following irradiation, commonly used in diagnosing Ataxia Telangiectasia and radiosensitive SCIDs (72, 73). Here, H2AX is linked to Ataxia-telangiectasia.