The Adiponectin gene expression was significantly downregulated in all tumor microenvironments (TME), including Nw-MA-T (RQ=0.06, p ≤ 0.001), Ob-PA-T (RQ=0.03, p ≤ 0.001), and Ob-MA-T (RQ=0.14, p ≤ 0.001), and undetermined in Nw-PA-T. This evidence concerns the gene ADIPOQ and neoplasm.