TNF and obesity due to melanocortin 4 receptor deficiency: In addition, Ob-MA-T had the most potent effect on the upregulation of all inflammatory genes by a factor near 28 for MMP9 (RQ=28.724, p ≤ 0.001, p3 ≤ 0.001), 4 for PTGS2 (RQ=4.163, p ≤ 0.001, p3 ≤ 0.001), 2 for TNF-α (RQ=2, p<0.05, p3<0.05) and for IL-6R (RQ=2.24, p ≤ 0.05) which may be due to obesity-associated inflammation (Table 3).