Following exposure to DCIS-like tumoroids, Nw adipose cells (PAs and MAs) might exhibit an iCAF phenotype with highly increased levels of LIF (Nw-PA-T: RQ=2.5, p ≤ 0.001; NwMA: RQ=1.8, p ≤ 0.05) (Figure 3B) and inflammatory cytokines (Figure 3C). This evidence concerns the gene LIF and ductal breast carcinoma in situ.