LEP and ductal breast carcinoma in situ: Within both Nw-TME and Ob-TME, DCIS-like tumoroids significantly upregulated the production of IL-8, a pro-tumorigenic cytokine that stimulates migration and invasion to promote invasion and metastasis but downregulated the production of IL-17A, MIP-1α, leptin, and adiponectin (Figure 4A).