The hormonal-related genes studied (ESR1, CYP19A1, and PGR) were not expressed by MCF10-DCIS cancer cells that are HER2-enriched (ER−, PR−, HER2+/ERBB2+) intrinsic molecular subtypes of breast cancer (33). This evidence concerns the gene CYP19A1 and ductal breast carcinoma in situ.