CAFs can exhibit diverse phenotypes and functions, influenced by various factors including tumor type, stage, and microenvironmental cues like cancer-associated myofibroblasts (myoCAF) characterized by the expression of α-SMA and FAP, and inflammatory cancer-associated fibroblast (iCAF) phenotypes characterized by expression of LIF and strong expression of inflammatory cytokines and chemokines. This evidence concerns the gene ACTA1 and cancer.