Previous research has predominantly examined specific clinical biomarkers linked to AKI in hypertension and other conditions, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury marker 1 (KIM-1), cystatin C (CysC), ST2, interleukin 18 (IL-18), and albuminuria (6–9). The gene discussed is IL18; the disease is acute kidney injury.