LEP and metabolic dysfunction-associated steatotic liver disease: This is indicated in the growing epidemiological evidence thatshows shift work has become a risk factor for hypertension, stroke,and coronary heart disease, while social jetlag may be associatedwith an elevation in triglyceride levels, a reduction in high-densitylipoprotein (HDL), and insulin sensitivity.15 Cardiovascular disease, nonalcoholic fatty liver disease (NAFLD),16 obesity, and leptin resistance17 are the suggested consequences of metabolic dysfunctiondue to circadian disruption.