This is indicated in the growing epidemiological evidence thatshows shift work has become a risk factor for hypertension, stroke,and coronary heart disease, while social jetlag may be associatedwith an elevation in triglyceride levels, a reduction in high-densitylipoprotein (HDL), and insulin sensitivity.15 Cardiovascular disease, nonalcoholic fatty liver disease (NAFLD),16 obesity, and leptin resistance17 are the suggested consequences of metabolic dysfunctiondue to circadian disruption. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.