INS and diabetes mellitus: Compared to the original treatment, the dose of basic insulin in diabetes patients did not change treated with SGLT-2i (WMD −0.27 [−0.58, 0.04], p = 0.086) and DPP-4i (WMD −4.95 [−11.18, 1.27], p = 0.119), respectively (Figure 2(d)).