NLRP3 and obesity due to melanocortin 4 receptor deficiency: In agreement with this, a previous body of research demonstrated a vital role for adipose tissue inflammation, specifically that of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3)-induced inflammation, in driving obesity-induced cognitive deficits; effects of which were shown to be mediated through IL-1-mediated microglial activation.