Thus, suggesting that NLRP3/IL-1β signaling may underlie correlations between visceral adiposity and cognitive impairments in human obesity.36 Notably, findings from Henry et al. demonstrate that obesity-induced increases in visceral adipose tissue expression of NLRP3 and IL-1β were further exacerbated in the presence of moderate TBI. The gene discussed is NLRP3; the disease is obesity disorder.