S100B and concussion: Future investigations could consider additional biomarkers, including those related to blood-based inflammatory markers, which have recently received increased attention in the context of mTBI.39 For instance, studies in adults have examined the diagnostic potential of IL10, both independently and in conjunction with markers such as GFAP, HFABP, and S100b.13 In the realm of pediatric mTBI, there is a pressing need to collaborate across multiple centers and recruit larger cohorts to advance our understanding.