The average change in reaction time for the high GluA1 autoantibody group was clinically significant (approximately thrice the amount needed for identification as a clinically reliable decline on ImPACT when utilizing an 80% confidence interval).35 Importantly, no concussions were reported in the high GluA1 autoantibody group, despite impaired reaction time findings, confirming that chronic head injury with cognitive impairment can be caused in college athletes over the course of a season without sustaining a concussion. The gene discussed is GRIA1; the disease is Cognitive impairment.