Table 5 demonstrates the correlation between IL-6 values and the disease activity parameters in patients with chronic hepatitis B. We noticed that CHB patients experienced higher IL-6 levels significantly correlated with higher ALT, AST, viral load (HBV-DNA PCR), and a more advanced fibrosis stage (r = 0.35, P=0.008; r = 0.41, P=0.002; r = 0.35, P=0.007; r = 0.28, P=0.03, respectively). This evidence concerns the gene GPT and chronic hepatitis B virus infection.