Similarly, the HBV viral load (p=0.03, OR = 2.45, and 95% CI: 1.69–3.65), IL-6 levels (p=0.04, OR = 3.45, and 95% CI: 2.01–6.9), and TRL2 variants (p=0.01, OR = 4.25, and 95% CI: 2.14–13.5) are independent risk factors associated with disease progression from cirrhosis to HCC. The gene discussed is IL6; the disease is Cirrhosis.