Similarly, for progression from liver cirrhosis to HCC model 3, the HBV viral load (p=0.03, OR = 2.45, and 95% CI: 1.69–3.65), IL-6 levels (p=0.04, OR = 3.45, and 95% CI: 2.01–6.9), and TRL2 rs3804099 polymorphism (p=0.01, OR = 4.25, and 95% CI: 2.14–13.5) are the independent risk factors (Table 8). This evidence concerns the gene IL6 and cirrhosis of liver.