GSDMD and metabolic dysfunction-associated steatohepatitis: Another animal study also using MCD-fed mice as the MASH model, some researchers have showed that the expression levels of GSDMD and GSDMD-NT in MASH subjects were increased compared to the control, and that the knockdown of Gsdmd conferred the protection against hepatic injury induced by MCD diet (Xu et al., 2018).