Also, pro-inflammatory RAGE signaling is well-known to cause amyloidogenesis, tau hyperphosphorylation and other AD pathologies (Cai et al., 2016), and genetic deletion of inflammatory genes, such as TNF-α, and inducible nitric oxide synthetase, ameliorated neuropathological features in various types of AD transgenic mice (Kummer et al., 2011; Paouri et al., 2017). This evidence concerns the gene TNF and Alzheimer disease.