Also, by restoring type 2 signaling through therapeutic injection of IL-33, IL-4 or IL-13, or augmenting hippocampal IL-4 with phosphatidyl serine (Nolan et al., 2005), neurosynaptic function might be preventatively enhanced or bolstered in mild cognitive impairment or in early AD. The gene discussed is IL13; the disease is Cognitive impairment.