MAPT and Alzheimer disease: Simultaneously, the astrocytic expression of the alarmin, IL-33, a member of the IL-1 cytokine family, becomes elevated during aging (Carlock et al., 2017), and IL-33 knockout even at middle age in mice leads to severe oxidative damage, defective repair of DNA double-strand breaks, neurosynaptic loss, and tau pathology similar to AD (Lou, 2021).