Also, by restoring type 2 signaling through therapeutic injection of IL-33, IL-4 or IL-13, or augmenting hippocampal IL-4 with phosphatidyl serine (Nolan et al., 2005), neurosynaptic function might be preventatively enhanced or bolstered in mild cognitive impairment or in early AD. This evidence concerns the gene IL33 and Cognitive impairment.