The context of IAS occurrence in the patient herein (type 2 diabetes mellitus with a history of oral antidiabetics and insulin analog treatment), her laboratory anomalies (absence of severe hypoglycemia during the 72-h fasting test, late postprandial hypoglycemia, high insulinemia with insulin/C-peptide ratio near or above 1, positive AIA), and the decrease in hypoglycemia episode frequency under dietary advice despite the persistence of strongly positive AIA two months after, are in line with data presented in the review of 795 IAS cases [6]. The gene discussed is INS; the disease is diabetes mellitus.