CD274 and non-small cell lung carcinoma: The purpose of this paper is to elaborate on the demographic and clinical characteristics of metastatic NSCLC patients diagnosed as PD-L1 positive (with over 50% positivity) who underwent first-line therapy with pembrolizumab and to show disparities between squamous and non-squamous NSCLC, segmented by the number (1, 2, 3, or more) and location of metastases (liver, bone, and brain, and other sites).