IL18 and periodontitis: The ROC curves indicated a high accuracy of salivary IL-1β, IL-18, and GSDMD levels as biomarkers of periodontitis and CHD (Figures 1B–G, 2B–G, and 3B–G), with an AUC of 1.0 for groups P, AS-C, and AS-P (P < 0.0001).