Studies have shown that STC-1 may promote tumor growth by activating signaling pathways such as PI3K/Akt and MAPK, facilitate tumor metastasis by affecting the degradation of the extracellular matrix, regulate the tumor microenvironment by promoting angiogenesis, and inhibit tumor cell apoptosis leading to chemotherapy resistance [22,23]. The gene discussed is AKT1; the disease is neoplasm.