To ascertain genomic and phenotypic alterations that associate with biallelic CDK12 loss (CDK12BAL) in PC, we analyzed several large datasets where deep molecular assessments of tumors included analyses of genomic alterations by whole exome sequencing (WES) or whole genome sequencing (WGS), and metrics of gene expression by RNAseq. This evidence concerns the gene CDK12 and pachyonychia congenita.