These results suggest that the suppression of ATM population/inflammation by STF inhibition of IRE1α is associated with the reversal of the obesity-suppressed expression of thermogenic/mitochondrial oxidation genes in adipose tissue to promote thermogenesis, in conjunction with STF’s action on the PGC1α expression in adipocytes. Here, ERN1 is linked to obesity due to melanocortin 4 receptor deficiency.