Our studies also showed that IRE1α inhibition diminishes the obesity-elicited pro-inflammatory ATM subpopulations including the newly identified CD9+ ATMs and adipose inflammation which is known to suppress thermogenesis (Sakamoto, Takahashi et al. 2013, Goto, Naknukool et al. 2016, Sakamoto, Nitta et al. 2016). The gene discussed is CD9; the disease is obesity due to melanocortin 4 receptor deficiency.