Male C57B/6J mice fed on HFD for 8 weeks gained significant glucose intolerance (Fig. S1C) and were treated with STF at 10 mg/kg of BW once daily for 4 weeks (Fig. S1D) via IP injection, a dose previously shown to significantly inhibits IRE1α RNase activity in vivo (Papandreou, Denko et al. 2011, Tufanli, Telkoparan Akillilar et al. 2017, Herlea-Pana, Eeda et al. 2021), while still on HFD. The gene discussed is ERN1; the disease is Glucose intolerance.