Our studies also showed that IRE1α inhibition diminishes the obesity-elicited pro-inflammatory ATM subpopulations including the newly identified CD9+ ATMs and adipose inflammation which is known to suppress thermogenesis (Sakamoto, Takahashi et al. 2013, Goto, Naknukool et al. 2016, Sakamoto, Nitta et al. 2016). This evidence concerns the gene ATM and obesity disorder.