G6PC1 and metabolic dysfunction-associated steatotic liver disease: Furthermore, because MASLD is associated with an impaired suppression of hepatic glucose output (Marchesini, Brizi et al. 2001), we assessed the expression of genes involved in gluconeogenesis, including glucose-6-phosphatase catalytic subunit (G6PC) and phosphoenolpyruvate carboxykinase (Pepck).