Since adipose tissue macrophage (ATM) accumulation plays important role in contributing to insulin resistance and obesity (Xu, Barnes et al. 2003, Lumeng, Bodzin et al. 2007), we investigate whether STF treatment impacts ATM accumulation in DIO mice as IRE1α activity was observed to be heightened in obese macrophages (Shan, Wang et al. 2017). Here, ERN1 is linked to obesity due to melanocortin 4 receptor deficiency.