This situation causes ACE2 to have a dual behavior in COVID-19: it is the gateway for SARS-CoV-2 into cells, causing infection and, on the other hand, it causes a decrease in its expression and profoundly impacts the regulation of vascular function, generating systemic damage, which can worsen the disease (Diaz, 2020; Tignanelli et al., 2020; Liu et al., 2021). The gene discussed is ACE2; the disease is COVID-19.