As mentioned, the sharp decrease in ACE2 expression in the lungs and other tissues by SARS-CoV-2 infection is highly detrimental to vascular health, generating a pro-constrictory and pro-coagulation environment, which plays a central role in COVID-19 pathogenesis (Ye et al., 2020; Li et al., 2021). The gene discussed is ACE2; the disease is COVID-19.