While STAT3 activation after TNFα and IL-6 was similar in the TSC2(−) and TSC2(+) AML cells, Tsc2(−/−) MEFs had higher sensitivity to IL-6 treatment, where a 4.9-fold STAT3 induction was observed (Fig. 2d). The gene discussed is TSC2; the disease is acute myeloid leukemia.