NFKB1 and acute myeloid leukemia: Surprisingly, we identified a biphasic response to NF-κB inhibition in TSC2(−) AML cells, with an initial increase in Y705-STAT3 phosphorylation that then dropped at the 24 and 48 h time points (0.8-fold and 0.6-fold, respectively) (Fig. 3c).