Autosomal recessive mutations in PARK19 predominantly cause juvenile- or early-onset PD, with atypical signs and symptoms characterized by poor L-DOPA responsiveness, pyramidal signs, dystonia, rapid disease course, mental retardation, and seizures and is one of multiple DNAJC genes associated with familial forms of PD (2, 5, 79–83). This evidence concerns the gene DNAJC6 and Parkinson disease.