For instance, we identified proteins related to APP and Aβ metabolism (APP, APOE, CLU, CLSTN1, NCSTN, APLP2, SPON1), immune response and inflammation (HLA-DRB1, HLA-DRB5, C1QC, C4A and C3 consistent in DS and EOAD; CD44, ICAM1 and MSN in EOAD and LOAD) and lysosomal-related functions (PPT1, TPP1, LAMP1, PSAP, CTSD). This evidence concerns the gene CLU and Dravet syndrome.